Researchers identify over 100 locations on the human genome associated with schizophrenia risk

Posted on March 5, 2015

Schizophrenia is a distressing psychological disorder, which predominantly affects young people and can run in families. However, there has been limited progress in uncovering the genetic risk factors associated with schizophrenia despite numerous international studies. Consequently, the development of new antipsychotic compounds have been hampered by a lack of pathophysiological understanding.

"The schizophrenia research community recognized recently that the only way to make a real genetic breakthrough was to perform a large-scale genomic study, combining numerous samples from different nationalities around the world," explains study investigator Jianjun Liu of the A*STAR Genome Institute of Singapore.

The consortium brought together genetic data collected from over 150,000 people across the globe, around 37,000 of whom were known schizophrenia sufferers. The researchers uncovered 128 schizophrenia associations at 108 regions on the human genome, 83 of which had not previously been reported in connection with schizophrenia. Many of the genes pinpointed can be found in the brain, but some are linked to tissues that play an important role in immunity (see image). This adds considerable weight to the speculation that schizophrenia is somehow connected to a defective immune system.

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Source material from Medical Express