Serotonin transporter a crucial pharmacological target of antidepressants

Posted on September 3, 2014

Photo: flickr

In the central nervous system, serotonergic transmission is critically regulated by serotonin reuptake through the serotonin transporter.

As a crucial pharmacological target of antidepressants, the role of erotonin transporter in treatment of major depression is well-established.

Dr. Chaokun Li and co-workers from Xinxiang Medical University in China cloned the human brain serotonin transporter into Xenopus oocytes, to establish an in vitro expression system.

Two-electrode voltage clamp recordings were used to detect serotonin transporter activity.

Their results show that mifepristone attenuates serotonin transporter activity by directly inhibiting the serotonin transporter, and suggests that the serotonin transporter is a pharmacological target of mifepristone for the treatment of psychotic depression.

The relevant article has been published in Neural Regeneration Research.

Article: " Mifepristone modulates serotonin transporter function," by Chaokun Li, Linlin Shan, Xinjuan Li, Linyu Wei, Dongliang Li (Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China)


Category(s):Depression, Post Partum Depression

Source material from Medical News Today


Mental Health News

  • Forgiveness and Emotional Freedom

    newsthumbThis article talks about how showing forgiveness is the best route to emotional healing and freedom.

  • Advantages of being Narcissistic

    newsthumbNarcissism has a negative connotation and is often seen as an undesirable trait to have. However, recent findings show that there are positive ...

  • Diving into Emotional Abuse

    newsthumbThere are often certain misconceptions and misunderstandings about the definition of Emotional Abuse and the effects that come with it. This article ...