Study links poor sleep quality to reduced brain gray matter

Posted on March 3, 2014

Subjective sleep quality is associated with gray matter volume independent of comorbid psychiatric conditions. Photo: flickr

A new study of Gulf War veterans found an association between poor sleep quality and reduced gray matter volume in the brain's frontal lobe, which helps control important processes such as working memory and executive function.

"Previous imaging studies have suggested that sleep disturbances may be associated with structural brain changes in certain regions of the frontal lobe," said lead author Linda Chao, associate adjunct professor in the Departments of Radiology and Biomedical Imaging and Psychiatry at the University of California, San Francisco. "The surprising thing about this study is that it suggests poor sleep quality is associated with reduced gray matter volume throughout the entire frontal lobe and also globally in the brain."

Results show that poorer subjective sleep quality was associated with reduced total cortical and regional frontal lobe gray matter volumes after controlling for potentially confounding variables such as posttraumatic stress disorder, depression, Gulf War Illness, trauma exposure and psychotropic medication use. The study may help explain the link between poor sleep quality and impaired psychosocial, physical and occupational functioning.

"This study emphasizes the importance of seeking medical help if you are troubled by the poor quality of your sleep," said American Academy of Sleep Medicine President Dr. M. Safwan Badr. "A board certified sleep medicine physician can identify the cause of your sleep problem and develop an effective treatment plan for you."

Total cortical, lobar gray matter, and hippocampal volumes were quantified from magnetic resonance imaging (MRI), and subjective sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Multiple linear regressions were used to determine the association of sleep quality with total and regional brain volumes.

According to the authors, the cross-sectional design of the study did not allow them to determine a causal relationship between sleep and frontal lobe volume. They noted that additional research is needed to determine if effective treatment of disturbed sleep leads to improved structural and functional integrity of the frontal lobes.


Category(s):Post Traumatic Stress Disorder (PTSD) / Trauma / Complex PTSD, Sleep Disorders

Source material from American Academy of Sleep Medicine


Mental Health News

  • Inequality as a disorder

    newsthumbEconomic inequality is one of the signs that foreshadows societal disorder. It can also negatively impact people’s lives and is highly associated ...

  • The Truth about Psychopaths

    newsthumbThis article talks about the common misconceptions people have about psychopaths and who they really are, what type of person they are and what drew ...

  • ADHD drugs worsen health

    newsthumbContrary to popular beliefs, studies have proven that drugs used to treat attention deficit hyperactivity disorder (ADHD) are ineffective in ...